SANH

Succinimidyl 6-hydrazinonicotinate acetone hydrazone (SANH; S-HyNic) is a heterobifunctional linker used for introducing protected hydrazinonicotinimide functional groups into proteins, peptides, surfaces and other primary amine containing molecules via its reactive N-hydroxysuccinimide ester terminus. Upon deprotection of the hydrazone functionality under acidic or neutral pH (4.5-7.4), the liberated hydrazine group can then react with aldehydes and ketones to form stable bonds. SANH has also been used extensively for the labeling of biomolecules with the SPECT imaging isotope, 99mTc [1-4].

Molecular Formula: C13H14N4O4
MW: 290.27
CAS # [362522-50-7]
Solubility: >50mg/mL in DMF

Purity: >90% by 1H NMR